Periampullary cancer is a cancer that forms near the ampulla of Vater, an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine.
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
It presents with painless jaundice which may be intermittent in nature due to the sloughing of the tumour tissue relieving the obstruction intermittently.